[alibaba/druid]线上环境运行一段时间就会出现以下报错信息，求大佬解答一下

Caused by: org.hibernate.exception.GenericJDBCException: Unable to acquire JDBC Connection at org.hibernate.exception.internal.StandardSQLExceptionConverter.convert(StandardSQLExceptionConverter.java:47) at org.hibernate.engine.jdbc.spi.SqlExceptionHelper.convert(SqlExceptionHelper.java:113) at org.hibernate.engine.jdbc.spi.SqlExceptionHelper.convert(SqlExceptionHelper.java:99) at org.hibernate.resource.jdbc.internal.LogicalConnectionManagedImpl.acquireConnectionIfNeeded(LogicalConnectionManagedImpl.java:109) at org.hibernate.resource.jdbc.internal.LogicalConnectionManagedImpl.getPhysicalConnection(LogicalConnectionManagedImpl.java:136) at org.hibernate.internal.SessionImpl.connection(SessionImpl.java:541) at sun.reflect.GeneratedMethodAccessor235.invoke(Unknown Source) at sun.reflect.DelegatingMethodAccessorImpl.invoke(Unknown Source) at java.lang.reflect.Method.invoke(Unknown Source) at org.springframework.util.ReflectionUtils.invokeMethod(ReflectionUtils.java:282) at org.springframework.util.ReflectionUtils.invokeMethod(ReflectionUtils.java:266) at org.springframework.orm.jpa.vendor.WinningHibernateJpaDialect$HibernateConnectionHandle.doGetConnection(WinningHibernateJpaDialect.java:340) at org.springframework.orm.jpa.vendor.WinningHibernateJpaDialect.beginTransaction(WinningHibernateJpaDialect.java:101) at org.springframework.orm.jpa.JpaTransactionManager.doBegin(JpaTransactionManager.java:402) ... 143 common frames omitted Caused by:com.alibaba.druid.pool.GetConnectionTimeoutException: wait millis 30001, active 0, maxActive 200, creating 1, createElapseMillis 258994534, createErrorCount 191 at com.alibaba.druid.pool.DruidDataSource.getConnectionInternal(DruidDataSource.java:1682) at com.alibaba.druid.pool.DruidDataSource.getConnectionDirect(DruidDataSource.java:1395) at com.alibaba.druid.filter.FilterChainImpl.dataSource_connect(FilterChainImpl.java:5059) at com.alibaba.druid.filter.logging.LogFilter.dataSource_getConnection(LogFilter.java:886) at com.alibaba.druid.filter.FilterChainImpl.dataSource_connect(FilterChainImpl.java:5055) at com.alibaba.druid.pool.DruidDataSource.getConnection(DruidDataSource.java:1373) at com.alibaba.druid.pool.DruidDataSource.getConnection(DruidDataSource.java:1365) at com.alibaba.druid.pool.DruidDataSource.getConnection(DruidDataSource.java:109) at org.hibernate.engine.jdbc.connections.internal.DatasourceConnectionProviderImpl.getConnection(DatasourceConnectionProviderImpl.java:122) at org.hibernate.internal.NonContextualJdbcConnectionAccess.obtainConnection(NonContextualJdbcConnectionAccess.java:35) at org.hibernate.resource.jdbc.internal.LogicalConnectionManagedImpl.acquireConnectionIfNeeded(LogicalConnectionManagedImpl.java:106) ... 153 common frames omitted